TY - JOUR
T1 - Task-related variation in airborne concentrations of laboratory animal allergens
T2 - Studies with Rat n I
AU - Eggleston, Peyton A.
AU - Newill, Carol A.
AU - Ansari, Aftab A.
AU - Pustelnik, Anita
AU - Lou, Sheau Rong
AU - Evans, Richard
AU - Marsh, David G.
AU - Longbottom, Joan L.
AU - Corn, Morton
N1 - Funding Information:
From the Department of *Pediatrics and **Medicine, School of Medicine. and the Departments of ***Environmental Health Sci-ences and lmmunologv and ****Infectious Diseases, School of Hygiene and Public Health, The Johns Hopkins University, Bal-timore. Md.; and from the *****Paediatric Department, Car-diothoracic Institute, London, England. Supported by National Institutes of Health Grants HL 30532, Al 21073, Contract NOI-AI-52591, and the Hospital for Con-sumptives of Maryland (Eudowood fund). Received for publication Sept. 27, 1988. Revised March 22, 1989. Acceptelj for publication March 22, 1989. Reprint requests: Peyton A. Eggleston, MD, Associate Professor. Department Pediatrics, CMSC 1103, The Johns Hopkins Hoa-pital, 601 N. Wolfe St., Baltimore, MD 21205. 111113011
PY - 1989/9
Y1 - 1989/9
N2 - To define airborne allergen exposure during various tasks with rats in a laboratory, concentrations of allergen Rat n I were measured by radioimmunoassay in extracts from filters in personal air sampling devices that were worn by laboratory workers while they were performing these tasks. The tasks included feeding, cage cleaning, handling, injection, surgery, and sacrifice. Median concentrations encountered during feeding or cleaning (21 ng/m3) and injection or handling (13 ng/m3) were higher than those associated with surgery or sacrifice (3.1 ng/m3; p < 0.01). Area samples in animal-holding rooms contained 3.4 ng/m3 during animal handling and 2.3 ng/m3 at other times. Very low concentrations were found in air outside the handling room, in unused laboratories, or outside air. We concluded that certain tasks incur a higher risk of allergen exposure but that exposure may occur anywhere within an animal laboratory environment.
AB - To define airborne allergen exposure during various tasks with rats in a laboratory, concentrations of allergen Rat n I were measured by radioimmunoassay in extracts from filters in personal air sampling devices that were worn by laboratory workers while they were performing these tasks. The tasks included feeding, cage cleaning, handling, injection, surgery, and sacrifice. Median concentrations encountered during feeding or cleaning (21 ng/m3) and injection or handling (13 ng/m3) were higher than those associated with surgery or sacrifice (3.1 ng/m3; p < 0.01). Area samples in animal-holding rooms contained 3.4 ng/m3 during animal handling and 2.3 ng/m3 at other times. Very low concentrations were found in air outside the handling room, in unused laboratories, or outside air. We concluded that certain tasks incur a higher risk of allergen exposure but that exposure may occur anywhere within an animal laboratory environment.
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U2 - 10.1016/0091-6749(89)90419-3
DO - 10.1016/0091-6749(89)90419-3
M3 - Article
C2 - 2778241
AN - SCOPUS:0024440785
SN - 0091-6749
VL - 84
SP - 347
EP - 352
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 3
ER -