Targeting voltage gated sodium channels NaV1.7, Na V1.8, and NaV1.9 for treatment of pathological cough

Yukiko Muroi, Bradley J. Undem

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Recent advances in our understanding of voltage-gated sodium channels (NaVs) lead to the rational hypothesis that drugs capable of selective blockade of NaV subtypes may be a safe and effective strategy for the treatment of unwanted cough. Among the nine NaV subtypes (NaV1.1-NaV1.9), the afferent nerves involved in initiating cough, in common with nociceptive neurons in the somatosensory system, express mainly NaV1.7, NaV1.8, and Na V1.9. Although knowledge about the effect of selectively blocking these channels on the cough reflex is limited, their biophysical properties indicate that each may contribute to the hypertussive and allotussive state that typifies subacute and chronic nonproductive cough.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalLung
Volume192
Issue number1
DOIs
StatePublished - Feb 2014

Keywords

  • C-fiber
  • Sodium channel
  • Vagus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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