Targeting the right regulatory t-cell population for tumor immunotherapy

Vivian L. Weiss; Timothy H. Lee; Elizabeth M. Jaffee; Todd D. Armstrong

doi:10.4161/onci.20664

Targeting the right regulatory t-cell population for tumor immunotherapy

Vivian L. Weiss, Timothy H. Lee, Elizabeth M. Jaffee, Todd D. Armstrong

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Regulatory T cells (T_regs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of T_regs, namely effector/memory CD25^low cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of T_reg-mediated immunosuppression.

Original language	English (US)
Pages (from-to)	1191-1193
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	7
DOIs	https://doi.org/10.4161/onci.20664
State	Published - 2012

Keywords

Anti-CD25
Cyclophosphamide
High avidity T-cells
Immunotherapy
T depletion
Tumor vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.20664

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title = "Targeting the right regulatory t-cell population for tumor immunotherapy",

abstract = "Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25low cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.",

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AU - Weiss, Vivian L.

AU - Lee, Timothy H.

AU - Jaffee, Elizabeth M.

AU - Armstrong, Todd D.

PY - 2012

Y1 - 2012

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AB - Regulatory T cells (Tregs) that suppress tumor-specific T cell-mediated immune responses are the subject of an intense wave of investigation. We recently reported that a subset of Tregs, namely effector/memory CD25low cells, are responsible for suppressing high avidity tumor-specific T cells in mouse mammary tumors. Here, we discuss additional findings that clarify this mechanism of Treg-mediated immunosuppression.

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KW - Cyclophosphamide

KW - High avidity T-cells

KW - Immunotherapy

KW - T depletion

KW - Tumor vaccine

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Targeting the right regulatory t-cell population for tumor immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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