Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

Robert A. Casero; Laurence J. Marton

doi:10.1038/nrd2243

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

Robert A. Casero, Laurence J. Marton

School of Medicine

Research output: Contribution to journal › Review article › peer-review

524 Scopus citations

Abstract

The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

Original language	English (US)
Pages (from-to)	373-390
Number of pages	18
Journal	Nature Reviews Drug Discovery
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/nrd2243
State	Published - May 2007

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/nrd2243

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title = "Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases",

abstract = "The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.",

author = "Casero, {Robert A.} and Marton, {Laurence J.}",

note = "Funding Information: The authors wish to thank J. Cleveland for his contributions in preparing BOX 1. Work in the Casero laboratory is supported by grants from the National Institutes of Health and the Patrick C. Walsh Prostate Cancer Research Fund for which R.A.C. is the Schwartz Scholar.",

year = "2007",

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AU - Marton, Laurence J.

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N2 - The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

AB - The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

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