Targeting metabolic cross talk between cancer cells and cancer-associated fibroblasts

Jin G. Jung, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Considering metabolic cross talk between CAFs and cancer as a metabolic target for cancer therapyTargeting the reverse Warburg effects via disruption of the “lactate shuttle” by MCT1/MCT 4 inhibitorsBlocking the function of CAFs, which promote cancer cell growth, by metforminUsing metformin to inhibit glycolysis of CAFsTargeting glutaminolysis by blocking the glutamine uptake of cancer cells from CAFsTargeting ketone bodies and ketosis in CAFsTargeting fatty acid metabolism, as a nutrient reservoir for cancer cell growth, from cancer-associated adipocytes (CAAs).

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages12
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cancer therapy
  • Cancer-associated adipocytes
  • Cancer-associated fibroblasts
  • Metabolism
  • Metabolites
  • Tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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