Abstract
Cancers express a large battery of genes by which they establish an immunosuppressive tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through transcriptional activation mediated by hypoxia-inducible factors HIF-1 and HIF-2. This review summarizes several recent reports describing hypoxia-induced mechanisms of immune evasion in sarcoma and breast, colorectal, hepatocellular, prostate and uterine cancer. These studies point to several novel therapeutic approaches to improve anti-tumor immunity and increase responses to immunotherapy.
Original language | English (US) |
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Pages (from-to) | 5-10 |
Number of pages | 6 |
Journal | Seminars in Cancer Biology |
Volume | 96 |
DOIs | |
State | Published - Nov 2023 |
Keywords
- Hypoxia-inducible factor
- Immune checkpoint inhibitor
- Immune evasion
- Immunotherapy
- Intratumoral hypoxia
ASJC Scopus subject areas
- Cancer Research