Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

When tissue perfusion is impaired, the resulting reduction in O2 availability activates hypoxia-inducible factor 1 (HIF-1), which mediates increased transcription of genes encoding multiple angiogenic factors including vascular endothelial growth factor, stromal-derived factor 1, placental growth factor, and angiopoietins, leading to the mobilization of bone marrow-derived angiogenic cells, increased angiogenesis, and arterial remodeling. These HIF- 1-dependent responses are impaired by aging or loss of function mutations at the locus encoding the HIF-1α subunit. in mouse models of limb ischemia and lung transplant rejection, the augmentation of HIF-1 activity by gene therapy or chemical inducers was associated with maintenance of tissue perfusion that prevented limb amputation and allograft rejection, respectively. Thus, targeting HIF-1 may be of therapeutic benefit in these clinical contexts and others in which impaired tissue perfusion plays a role in disease pathogenesis.

Original languageEnglish (US)
Pages (from-to)361-363
Number of pages3
JournalJournal of investigative medicine : the official publication of the American Federation for Clinical Research
Volume64
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • angiogenesis
  • arteriogenesis
  • bronchiolitis obliterans
  • critical limb ischemia
  • desferrioxamine
  • dimethyloxalylglycine
  • prolyl hydroxylases

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Targeting hypoxia-inducible factor 1 to stimulate tissue vascularization'. Together they form a unique fingerprint.

Cite this