Abstract
Metabolic reprogramming is one of the biochemical signatures of cancer cells. Particularly, aerobic glycolysis (i.e. the process of conversion of glucose into pyruvate followed by fermentation into lactate even in the presence of oxygen) has been of immense interest due to its impact not only on cancer cells but on the tumor microenvironment as well. Conceptual advancement in understanding the oncogenic regulation of glycolysis and multifunctional properties of glycolytic enzymes underscore the relevance and significance of targeting glycolysis in cancer cells. This chapter will discuss, in the light of recent research the intricacies of glycolytic adaptation in cancer cells, and the rationale for exploiting it for therapeutic intervention.
Original language | English (US) |
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Title of host publication | Stress Response Pathways in Cancer |
Subtitle of host publication | From Molecular Targets to Novel Therapeutics |
Publisher | Springer Netherlands |
Pages | 331-344 |
Number of pages | 14 |
ISBN (Electronic) | 9789401794213 |
ISBN (Print) | 9789401794206 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- ATP
- Acidosis
- Aerobic glycolysis
- Antiglycolytic therapy
- Apoptosis
- Chemoresistance
- Embden-Meyerhof-Parnas pathway
- Glycolysis
- Hypoxia
- Metabolic reprogram
- Metabolic stress
- Microenvironment
- Monocarboxylate transporters
- Reactive oxygen species
- Warburg effect
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology