TY - JOUR
T1 - Targeted Photoacoustic Imaging of Brain Tumor Mediated by Neutrophils Engineered with Lipid-Based Molecular Probe
AU - Liu, Xingang
AU - Duan, Yukun
AU - Hu, Dehong
AU - Wu, Min
AU - Chen, Chengjian
AU - Ghode, Pramila Baban
AU - Magarajah, Gayathiri
AU - Thakor, Nitish
AU - Liu, Xin
AU - Liu, Chengbo
AU - Sheng, Zonghai
AU - Zheng, Hairong
AU - Liu, Bin
N1 - Funding Information:
We thank Singapore National Research Foundation (No. R279-000-483-281) and NUS (No. R279-000-482-133) for financial support. This work was also partially supported by Science and Technology Key Project of Shenzhen (Nos. JCYJ20200109114612308, JCYJ20190812163614809), the National Natural Science Foundation of China (Nos. 91859117, 81771906, 81971638), Shenzhen Key Laboratory of Ultrasound Imaging and Therapy (No. ZDSYS201802061806314), CAS Key Laboratory of Health Informatics (No. 2011DP173015), Shenzhen Double Chain Grant (No. [2018]256).
Funding Information:
We thank Singapore National Research Foundation (No. R279-000-483-281) and NUS (No. R279-000-482-133) for financial support. This work was also partially supported by Science and Technology Key Project of Shenzhen (Nos. JCYJ20200109114612308, JCYJ20190812163614809), the National Natural Science Foundation of China (Nos. 91859117, 81771906 81971638), Shenzhen Key Laboratory of Ultrasound Imaging and Therapy (No. ZDSYS201802061806314), CAS Key Laboratory of Health Informatics (No. 2011DP173015), Shenzhen Double Chain Grant (No. [2018]256).
Publisher Copyright:
©
PY - 2021
Y1 - 2021
N2 - The delivery of imaging agents to brain tumor sites has been a longstanding hindrance, because of the presence of blood-brain barriers (BBB) and the complex brain tumor microenvironment. The living cell-based delivery system has shown tantalizing prospects for therapeutic applications targeting oncological diseases. Herein, we design a lipid-decorated molecular photoacoustic contrast agent TFML, which can effectively label harvested live neutrophils without affecting the activation and transmigration functions. After labeling neutrophils with TFML probes, TFML-labeled neutrophil (TFML-NE) was adoptively transferred into the recipient body and demonstrated strong PA signals, good brain tumor-targeting capability, and was applied for mice glioblastoma multiforme (GBM) detection. The successful development of TFML probes for neutrophil labeling and brain tumor targeting PAI presents a promising prospect for neutrophil-based nanotherapeutics studies.
AB - The delivery of imaging agents to brain tumor sites has been a longstanding hindrance, because of the presence of blood-brain barriers (BBB) and the complex brain tumor microenvironment. The living cell-based delivery system has shown tantalizing prospects for therapeutic applications targeting oncological diseases. Herein, we design a lipid-decorated molecular photoacoustic contrast agent TFML, which can effectively label harvested live neutrophils without affecting the activation and transmigration functions. After labeling neutrophils with TFML probes, TFML-labeled neutrophil (TFML-NE) was adoptively transferred into the recipient body and demonstrated strong PA signals, good brain tumor-targeting capability, and was applied for mice glioblastoma multiforme (GBM) detection. The successful development of TFML probes for neutrophil labeling and brain tumor targeting PAI presents a promising prospect for neutrophil-based nanotherapeutics studies.
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U2 - 10.1021/acsmaterialslett.1c00329
DO - 10.1021/acsmaterialslett.1c00329
M3 - Article
AN - SCOPUS:85113378279
SN - 2639-4979
VL - 3
SP - 1284
EP - 1290
JO - ACS Materials Letters
JF - ACS Materials Letters
ER -