Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Iddo Paldor; Kaisorn Chaichana; Henry Brem; Betty M. Tyler

doi:10.1159/000469688

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Iddo Paldor
, Kaisorn Chaichana
, Henry Brem
, Betty M. Tyler

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.

Original language	English (US)
Pages (from-to)	159-171
Number of pages	13
Journal	Progress in neurological surgery
Volume	32
DOIs	https://doi.org/10.1159/000469688
State	Published - Jan 1 2018

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1159/000469688

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AU - Brem, Henry

AU - Tyler, Betty M.

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Y1 - 2018/1/1

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AB - Systemic chemotherapy of malignant brain tumors has failed to achieve sufficient drug concentrations at the neoplasm site and frequently results in severe toxicities. Therefore, the local application of several anticancer agents, oncolytic viruses and vectors for gene therapy, immune-modifying preparations, and angiogenesis inhibitors has been investigated widely. Various modes of their administration were introduced, including intratumoral injections, implantation of reservoirs or pumps, convection-enhanced delivery, and use of nanocarriers, thermoreversible gels, microchips, and drug-loaded polymers. Many of these therapeutic approaches have shown promising results in management of high-grade gliomas.

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JO - Progress in neurological surgery

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ER -

Targeted Local Therapy for Management of Intracranial High-Grade Gliomas

Abstract

ASJC Scopus subject areas

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