@article{be3417a2469f4d5fad51fda40d6361c5,
title = "Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction",
abstract = "Despite evidence demonstrating the role of β1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt β1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that β1-integrin expression is critical for the initiation of mammary tumorigenesis in vivo, and for maintaining the proliferative capacity of late-stage tumor cells. These observations provide a direct demonstration that β1-integrin plays a critical role in both the initiation and maintenance of mammary tumor growth in vivo.",
author = "White, {Donald E.} and Kurpios, {Natasza A.} and Dongmei Zuo and Hassell, {John A.} and Sandra Blaess and Ulrich Mueller and Muller, {William J.}",
note = "Funding Information: We wish to thank Dr. Mina J. Bissell for useful discussions regarding this work. We would also like to thank Dr. Frank Graham and Dr. Steven Dilworth, for supplying the adenovirus vectors and anti-PyV MT antibody, respectively. This research was funded by grants from the National Institutes of Health (W.J.M.), the Canadian Institutes of Health Research (J.A.H.), and the Canadian Breast Cancer Research Alliance (W.J.M., J.A.H.). D.E.W. and N.A.K. were supported by predoctoral research scholarships from the US Department of Defense Breast Cancer Research Initiative (DAMD17-99-1-9284 and DAMD17-02-1-048, respectively). W.J.M. is the recipient of a CRC chair in molecular oncology, McGill University.",
year = "2004",
month = aug,
doi = "10.1016/j.ccr.2004.06.025",
language = "English (US)",
volume = "6",
pages = "159--170",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}