Targeted and armed oncolytic adenovirus via chemoselective modification

Partha S. Banerjee; Edison S. Zuniga; Iwao Ojima; Isaac S. Carrico

doi:10.1016/j.bmcl.2011.05.039

Targeted and armed oncolytic adenovirus via chemoselective modification

Partha S. Banerjee, Edison S. Zuniga, Iwao Ojima, Isaac S. Carrico

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.

Original language	English (US)
Pages (from-to)	4985-4988
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2011.05.039
State	Published - Sep 1 2011
Externally published	Yes

Keywords

Adenovirus
Chemoselective
Click
Gene delivery
Non-canonical
Oncolytic
Paclitaxel
Staudinger
Taxoid
Unnatural

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.05.039

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abstract = "Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.",

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AU - Banerjee, Partha S.

AU - Zuniga, Edison S.

AU - Ojima, Iwao

AU - Carrico, Isaac S.

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AB - Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.

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KW - Chemoselective

KW - Click

KW - Gene delivery

KW - Non-canonical

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Targeted and armed oncolytic adenovirus via chemoselective modification

Abstract

Keywords

ASJC Scopus subject areas

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