Tails of RNA polymerase II

Jeffry L. Corden

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations


Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for polymerase function in vivo. Although the nature of this essential function is unknown, actively transcribing RNA polymerase II is known to be multiphosphorylated on this repetitive domain.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalTrends in biochemical sciences
Issue number10
StatePublished - Oct 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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