T regulatory cells and transplantation tolerance

Vijay S. Gorantla, Stefan Schneeberger, Gerald Brandacher, Robert Sucher, Dong Zhang, W. P.Andrew Lee, Xin Xiao Zheng

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

Original languageEnglish (US)
Pages (from-to)147-159
Number of pages13
JournalTransplantation Reviews
Issue number3
StatePublished - Jul 2010
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Surgery


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