T-Cell Receptor Signaling to NF-κB

R. R. McCully, Joel L Pomerantz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The activation of the nuclear factor kappa B (NF-κB) family of transcription factors is a key step in the adaptive immune response, in which lymphocytes respond to antigen by proliferating and generating multiple effector responses geared toward eradicating a pathogen. NF-κB activation is required for the proliferation, survival, and differentiation of lymphocytes, as well as the production of pro-inflammatory responses. NF-κB normally remains dormant in the cytosol, poised for activation. Multiple receptors can activate NF-κB, including antigen receptors on T and B cells. In the adaptive immune response, antigen receptor signaling leads to the activation of a signaling cascade that culminates in the activation of the IκB kinase (IKK) complex, which phosphorylates IκBs, marking them for destruction, allowing NF-κB to enter the nucleus and activate the transcription of genes involved in the immune response. This article provides an overview of the regulated signaling events in this pathway.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
StatePublished - Feb 15 2013


  • A20
  • Bcl10
  • CARD11
  • IKK complex
  • Immune response
  • Lymphocyte activation
  • MALT1
  • NF-κB
  • Signal transduction
  • T-cell receptor
  • TAK1
  • TRAF6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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