TY - JOUR
T1 - T cell memory in malaria
AU - Cockburn, Ian A.
AU - Zavala, Fidel
N1 - Funding Information:
FZ receives financial support from the National Institutes of Health (Grant number AI044375) and the Johns Hopkins Malaria Research Institute. The authors thank Dr. Lucy Morris (Carnegie Institution of Washington) for her comments on the manuscript.
PY - 2007/8
Y1 - 2007/8
N2 - The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed. Studies using these models have found that, unexpectedly, T cell memory in malaria is not noticeably defective. However, if T cell memory is 'normal' why are people not better protected? We suggest this is because protective immunity and T cell memory do not always correlate; moreover, T cells alone may simply not be able to provide the type of antibody-mediated sterilizing immunity induced by traditional vaccines.
AB - The observation that individuals living in malaria endemic areas fail to develop sterilizing immunity to malaria infection has led to the assumption that malaria-specific immune responses are sub-optimal. Recently, T cell receptor (TCR) transgenic mice specific for the sporozoite and blood stages of the malaria parasite have been developed. Studies using these models have found that, unexpectedly, T cell memory in malaria is not noticeably defective. However, if T cell memory is 'normal' why are people not better protected? We suggest this is because protective immunity and T cell memory do not always correlate; moreover, T cells alone may simply not be able to provide the type of antibody-mediated sterilizing immunity induced by traditional vaccines.
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U2 - 10.1016/j.coi.2007.05.008
DO - 10.1016/j.coi.2007.05.008
M3 - Review article
C2 - 17624749
AN - SCOPUS:34548019006
SN - 0952-7915
VL - 19
SP - 424
EP - 429
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -