T-cell-deficient mice display normal recovery from experimental rotavirus infection

J. Eiden, H. M. Lederman, S. Vonderfecht, R. Yolken

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Rotaviruses are common causes of diarrhea in animals and humans. Little is known, however, about the components of the host response to these viruses. Rotavirus infection was studied in athymic mice experimentally infected with murine rotavirus. Neonatal T-cell-deficient mice experienced a self-limited gastrointestinal infection which was identical to that observed in age-matched immunocompetent mice. Adult T-cell-deficient seronegative mice and age-matched normal mice showed a similar extent of resistance to symptomatic rotavirus infection. In both cases, the infection was resolved without the generation of antirotavirus antibody. These studies indicate that host defense against murein rotavirus requires neither functional T-lymphocytes nor specific antiviral antibody.

Original languageEnglish (US)
Pages (from-to)706-708
Number of pages3
JournalJournal of virology
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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