T cell cytokines and the risk of blood stream infection in extremely low birth weight infants

Robert L. Schelonka, Akhil Maheshwari, Waldemar A. Carlo, Sarah Taylor, Nellie I. Hansen, Diana E. Schendel, Poul Thorsen, Kristin Skogstrand, David M. Hougaard, Rosemary D. Higgins

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Cytokines mediate the host immune response to infectious micro-organisms. The objective of this study was to determine whether immune regulatory interleukins (IL-4, IL-5, IL-6, and IL-10) and inflammatory cytokines (Interferon-γ [INF-γ], tumor necrosis factor-β [TNF-β], IL-2, and IL-17) are associated with an increased risk of developing blood stream bacterial/fungal infection (BSI) in extremely low birth weight (ELBW) infants. ELBW infants from 17 NICHD Neonatal Research Network centers without early onset sepsis were studied. Cytokines were measured from blood on days 1, 3, 7, 14, and 21 after birth. 996 ELBW infants contributed a minimum of 4080 unique measurements for each cytokine during the five sampling periods. Infants with BSI had lower levels of the inflammatory cytokines IL-17 (p=0.01), and higher levels of the regulatory cytokines, IL-6 (p=0.01) and IL-10 (p< 0.001). Higher levels of regulatory cytokines relative to pro-inflammatory cytokines were associated with increased risk of BSI even after adjusting for confounding variables. In ELBW infants, the ratio of immune regulatory cytokines to inflammatory cytokines was associated with development of BSI. Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
Issue number2
StatePublished - Feb 2011
Externally publishedYes


  • Cytokine
  • Infection
  • Neonate
  • Sepsis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Molecular Biology
  • Hematology


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