Systems pharmacogenomics in yeast

Patrick Cahan; Sharon Marsh; Howard L. McLeod

doi:10.2217/14622416.7.2.255

Systems pharmacogenomics in yeast

Patrick Cahan, Sharon Marsh, Howard L. McLeod

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Despite intense study, the mechanistic and therapeutic differences in cellular responses to DNA-damaging agents are not fully understood. In order to expand knowledge of DNA damage, the authors of this study assayed the effects of 12 anticancer agents on the complete pool of approximately 4700 homozygous deletion strains of Saccharomyces cerevisiae. The screens identified genes in well-characterized DNA, in addition to genes whose role in DNA-damage-response pathways had not previously been established.

Original language	English (US)
Pages (from-to)	255-259
Number of pages	5
Journal	Pharmacogenomics
Volume	7
Issue number	2
DOIs	https://doi.org/10.2217/14622416.7.2.255
State	Published - Mar 2006
Externally published	Yes

Keywords

Chemotheraphy
Pharmacogenomics
Resistance
Systems biology

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology

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10.2217/14622416.7.2.255

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AU - Marsh, Sharon

AU - McLeod, Howard L.

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AB - Despite intense study, the mechanistic and therapeutic differences in cellular responses to DNA-damaging agents are not fully understood. In order to expand knowledge of DNA damage, the authors of this study assayed the effects of 12 anticancer agents on the complete pool of approximately 4700 homozygous deletion strains of Saccharomyces cerevisiae. The screens identified genes in well-characterized DNA, in addition to genes whose role in DNA-damage-response pathways had not previously been established.

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KW - Pharmacogenomics

KW - Resistance

KW - Systems biology

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Systems pharmacogenomics in yeast

Abstract

Keywords

ASJC Scopus subject areas

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