Systems pharmacogenomics in yeast

Patrick Cahan, Sharon Marsh, Howard L. McLeod

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Despite intense study, the mechanistic and therapeutic differences in cellular responses to DNA-damaging agents are not fully understood. In order to expand knowledge of DNA damage, the authors of this study assayed the effects of 12 anticancer agents on the complete pool of approximately 4700 homozygous deletion strains of Saccharomyces cerevisiae. The screens identified genes in well-characterized DNA, in addition to genes whose role in DNA-damage-response pathways had not previously been established.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
Issue number2
StatePublished - Mar 2006
Externally publishedYes


  • Chemotheraphy
  • Pharmacogenomics
  • Resistance
  • Systems biology

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology


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