Systems immunology spanning tumors, lymph nodes, and periphery

Dimitrios N. Sidiropoulos; Won Jin Ho; Elizabeth M. Jaffee; Luciane T. Kagohara; Elana J. Fertig

doi:10.1016/j.crmeth.2023.100670

Systems immunology spanning tumors, lymph nodes, and periphery

Dimitrios N. Sidiropoulos, Won Jin Ho, Elizabeth M. Jaffee, Luciane T. Kagohara, Elana J. Fertig

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic interactions between immune and cancer cells contribute to disease progression. Lymphocytes are activated in lymph nodes, traffic through the periphery, and impact cancer progression through their interactions with tumor cells. As a result, therapeutic response and resistance are mediated across tissues, and a comprehensive understanding of lymphocyte dynamics requires a systems-level approach. In this review, we highlight experimental and computational methods that can leverage the study of leukocyte trafficking through an immunomics lens and reveal how adaptive immunity shapes cancer.

Original language	English (US)
Article number	100670
Journal	Cell Reports Methods
Volume	3
Issue number	12
DOIs	https://doi.org/10.1016/j.crmeth.2023.100670
State	Published - Dec 18 2023

Keywords

CP: Immunology

ASJC Scopus subject areas

Biotechnology
Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Genetics
Radiology Nuclear Medicine and imaging
Computer Science Applications

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10.1016/j.crmeth.2023.100670

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title = "Systems immunology spanning tumors, lymph nodes, and periphery",

abstract = "The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic interactions between immune and cancer cells contribute to disease progression. Lymphocytes are activated in lymph nodes, traffic through the periphery, and impact cancer progression through their interactions with tumor cells. As a result, therapeutic response and resistance are mediated across tissues, and a comprehensive understanding of lymphocyte dynamics requires a systems-level approach. In this review, we highlight experimental and computational methods that can leverage the study of leukocyte trafficking through an immunomics lens and reveal how adaptive immunity shapes cancer.",

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author = "Sidiropoulos, {Dimitrios N.} and Ho, {Won Jin} and Jaffee, {Elizabeth M.} and Kagohara, {Luciane T.} and Fertig, {Elana J.}",

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AU - Sidiropoulos, Dimitrios N.

AU - Ho, Won Jin

AU - Jaffee, Elizabeth M.

AU - Kagohara, Luciane T.

AU - Fertig, Elana J.

PY - 2023/12/18

Y1 - 2023/12/18

N2 - The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic interactions between immune and cancer cells contribute to disease progression. Lymphocytes are activated in lymph nodes, traffic through the periphery, and impact cancer progression through their interactions with tumor cells. As a result, therapeutic response and resistance are mediated across tissues, and a comprehensive understanding of lymphocyte dynamics requires a systems-level approach. In this review, we highlight experimental and computational methods that can leverage the study of leukocyte trafficking through an immunomics lens and reveal how adaptive immunity shapes cancer.

AB - The immune system defines a complex network of tissues and cell types that orchestrate responses across the body in a dynamic manner. The local and systemic interactions between immune and cancer cells contribute to disease progression. Lymphocytes are activated in lymph nodes, traffic through the periphery, and impact cancer progression through their interactions with tumor cells. As a result, therapeutic response and resistance are mediated across tissues, and a comprehensive understanding of lymphocyte dynamics requires a systems-level approach. In this review, we highlight experimental and computational methods that can leverage the study of leukocyte trafficking through an immunomics lens and reveal how adaptive immunity shapes cancer.

KW - CP: Immunology

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DO - 10.1016/j.crmeth.2023.100670

M3 - Review article

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SN - 2667-2375

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JO - Cell Reports Methods

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ER -

Systems immunology spanning tumors, lymph nodes, and periphery

Abstract

Keywords

ASJC Scopus subject areas

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