Systems biology: The role of engineering in the reverse engineering of biological signaling

Pablo A. Iglesias

doi:10.3390/cells2020393

Systems biology: The role of engineering in the reverse engineering of biological signaling

Pablo A. Iglesias

Whiting School of Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells.

Original language	English (US)
Pages (from-to)	393-413
Number of pages	21
Journal	Cells
Volume	2
Issue number	2
DOIs	https://doi.org/10.3390/cells2020393
State	Published - May 31 2013

Keywords

Control engineering
Homeostasis
Information theory
Signal processing
Statistical inference

ASJC Scopus subject areas

Medicine(all)

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10.3390/cells2020393

Cite this

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abstract = "One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells.",

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AB - One of the principle tasks of systems biology has been the reverse engineering of signaling networks. Because of the striking similarities to engineering systems, a number of analysis and design tools from engineering disciplines have been used in this process. This review looks at several examples including the analysis of homeostasis using control theory, the attenuation of noise using signal processing, statistical inference and the use of information theory to understand both binary decision systems and the response of eukaryotic chemotactic cells.

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KW - Homeostasis

KW - Information theory

KW - Signal processing

KW - Statistical inference

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Systems biology: The role of engineering in the reverse engineering of biological signaling

Abstract

Keywords

ASJC Scopus subject areas

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