TY - JOUR
T1 - Systems biology of oxygen homeostasis
AU - Samanta, Debangshu
AU - Prabhakar, Nanduri R.
AU - Semenza, Gregg L.
N1 - Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382. For further resources related to this article, please visit the WIREs website.
AB - Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O2 supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O2 sensing, O2 delivery, O2 utilization, and systemic O2 sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382. For further resources related to this article, please visit the WIREs website.
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U2 - 10.1002/wsbm.1382
DO - 10.1002/wsbm.1382
M3 - Review article
C2 - 28221004
AN - SCOPUS:85013443407
SN - 1939-5094
VL - 9
JO - Wiley Interdisciplinary Reviews: Systems Biology and Medicine
JF - Wiley Interdisciplinary Reviews: Systems Biology and Medicine
IS - 4
M1 - e1382
ER -