Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases

Yu Zhang; Chen Zhao; Aleksander S. Popel

doi:10.1016/B978-0-12-822546-2.00021-6

Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases

Yu Zhang, Chen Zhao, Aleksander S. Popel

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Angiogenesis is an important biological process involved in development, growth, reproduction, and wound healing. Dysregulation of angiogenesis is linked to many diseases, including cancer, ocular diseases, and cardiovascular diseases. Angiogenesis is a highly regulated process that involves a plethora of cells and cellular signaling events, including their activation, downstream signaling, regulation, and cross-talk. Computational modeling provides a powerful means of investigating the complex reaction network formed by these molecular and cellular events at the systems level. Here, we describe how mechanistic systems biology modeling of some of the major cellular signaling pathways at the molecular and cellular levels informs and provides insights for the understanding of angiogenesis in physiology and disease.

Original language	English (US)
Title of host publication	The Vasculome
Subtitle of host publication	From Many, One
Publisher	Elsevier
Pages	163-172
Number of pages	10
ISBN (Electronic)	9780128225462
ISBN (Print)	9780128225479
DOIs	https://doi.org/10.1016/B978-0-12-822546-2.00021-6
State	Published - Jan 1 2022

Keywords

Angiogenesis
Computational model
Endothelial cell
Macrophage
Signaling pathway
Systems biology

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-822546-2.00021-6

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abstract = "Angiogenesis is an important biological process involved in development, growth, reproduction, and wound healing. Dysregulation of angiogenesis is linked to many diseases, including cancer, ocular diseases, and cardiovascular diseases. Angiogenesis is a highly regulated process that involves a plethora of cells and cellular signaling events, including their activation, downstream signaling, regulation, and cross-talk. Computational modeling provides a powerful means of investigating the complex reaction network formed by these molecular and cellular events at the systems level. Here, we describe how mechanistic systems biology modeling of some of the major cellular signaling pathways at the molecular and cellular levels informs and provides insights for the understanding of angiogenesis in physiology and disease.",

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AB - Angiogenesis is an important biological process involved in development, growth, reproduction, and wound healing. Dysregulation of angiogenesis is linked to many diseases, including cancer, ocular diseases, and cardiovascular diseases. Angiogenesis is a highly regulated process that involves a plethora of cells and cellular signaling events, including their activation, downstream signaling, regulation, and cross-talk. Computational modeling provides a powerful means of investigating the complex reaction network formed by these molecular and cellular events at the systems level. Here, we describe how mechanistic systems biology modeling of some of the major cellular signaling pathways at the molecular and cellular levels informs and provides insights for the understanding of angiogenesis in physiology and disease.

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KW - Endothelial cell

KW - Macrophage

KW - Signaling pathway

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ER -

Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases

Abstract

Keywords

ASJC Scopus subject areas

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