Abstract
Background: SystemicRNAinterference deficiency-1 (SID-1) is a membrane protein required for cellular uptake ofRNAin C. elegans. Results: SID-1 extracellular domain selectively binds long dsRNA. Conclusion: Binding affinity between SID-1 ECD and dsRNA is related to RNA transport efficiency by SID-1. Significance: This defines SID-1 ECD as a functional domain for dsRNA recognition.
Original language | English (US) |
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Pages (from-to) | 18904-18913 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 31 |
DOIs | |
State | Published - Jul 31 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology