Systemic pharmacokinetics of rifaximin in volunteers with shigellosis

David N. Taylor; Robin McKenzie; Anna Durbin; Colleen Carpenter; Robert Haake; A. Louis Bourgeois

doi:10.1128/AAC.01108-07

Systemic pharmacokinetics of rifaximin in volunteers with shigellosis

David N. Taylor, Robin McKenzie, Anna Durbin, Colleen Carpenter, Robert Haake, A. Louis Bourgeois

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.

Original language	English (US)
Pages (from-to)	1179-1181
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01108-07
State	Published - Mar 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.01108-07

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abstract = "Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.",

author = "Taylor, {David N.} and Robin McKenzie and Anna Durbin and Colleen Carpenter and Robert Haake and Bourgeois, {A. Louis}",

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AU - McKenzie, Robin

AU - Durbin, Anna

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AU - Haake, Robert

AU - Bourgeois, A. Louis

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AB - Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.

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Systemic pharmacokinetics of rifaximin in volunteers with shigellosis

Abstract

ASJC Scopus subject areas

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