Systemic diseases affecting the GI tract: A review of clinical and histopathologic manifestations

Maryam K. Pezhouh; Dora Lam-Himlin; Atif Zaheer; Lysandra Voltaggio

doi:10.1016/j.anndiagpath.2024.152351

Systemic diseases affecting the GI tract: A review of clinical and histopathologic manifestations

Maryam K. Pezhouh
, Dora Lam-Himlin
, Atif Zaheer
, Lysandra Voltaggio

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

A variety of systemic diseases may affect the gastrointestinal (GI) tract. Since the GI tract responds to injury in limited ways, identifying these processes may be challenging, especially on small endoscopic biopsies. This article reviews the clinicopathologic features of commonly encountered systemic diseases affecting the tubular GI tract: sarcoidosis, graft vs. host disease, mast cell disorders, systemic sclerosis, and IgG-4 related disease. In addition, we offer guidance in differentiating them from their mimics.

Original language	English (US)
Article number	152351
Journal	Annals of Diagnostic Pathology
Volume	73
DOIs	https://doi.org/10.1016/j.anndiagpath.2024.152351
State	Published - Dec 2024

Keywords

Amyloidosis
Graft versus host disease
Mast cell disorders
Review
Systemic disease

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.anndiagpath.2024.152351

Cite this

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title = "Systemic diseases affecting the GI tract: A review of clinical and histopathologic manifestations",

abstract = "A variety of systemic diseases may affect the gastrointestinal (GI) tract. Since the GI tract responds to injury in limited ways, identifying these processes may be challenging, especially on small endoscopic biopsies. This article reviews the clinicopathologic features of commonly encountered systemic diseases affecting the tubular GI tract: sarcoidosis, graft vs. host disease, mast cell disorders, systemic sclerosis, and IgG-4 related disease. In addition, we offer guidance in differentiating them from their mimics.",

keywords = "Amyloidosis, Graft versus host disease, Mast cell disorders, Review, Systemic disease",

author = "Pezhouh, \{Maryam K.\} and Dora Lam-Himlin and Atif Zaheer and Lysandra Voltaggio",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = dec,

doi = "10.1016/j.anndiagpath.2024.152351",

language = "English (US)",

volume = "73",

journal = "Annals of Diagnostic Pathology",

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T2 - A review of clinical and histopathologic manifestations

AU - Pezhouh, Maryam K.

AU - Lam-Himlin, Dora

AU - Zaheer, Atif

AU - Voltaggio, Lysandra

PY - 2024/12

Y1 - 2024/12

N2 - A variety of systemic diseases may affect the gastrointestinal (GI) tract. Since the GI tract responds to injury in limited ways, identifying these processes may be challenging, especially on small endoscopic biopsies. This article reviews the clinicopathologic features of commonly encountered systemic diseases affecting the tubular GI tract: sarcoidosis, graft vs. host disease, mast cell disorders, systemic sclerosis, and IgG-4 related disease. In addition, we offer guidance in differentiating them from their mimics.

AB - A variety of systemic diseases may affect the gastrointestinal (GI) tract. Since the GI tract responds to injury in limited ways, identifying these processes may be challenging, especially on small endoscopic biopsies. This article reviews the clinicopathologic features of commonly encountered systemic diseases affecting the tubular GI tract: sarcoidosis, graft vs. host disease, mast cell disorders, systemic sclerosis, and IgG-4 related disease. In addition, we offer guidance in differentiating them from their mimics.

KW - Amyloidosis

KW - Graft versus host disease

KW - Mast cell disorders

KW - Review

KW - Systemic disease

UR - https://www.scopus.com/pages/publications/85198067135

UR - https://www.scopus.com/pages/publications/85198067135#tab=citedBy

U2 - 10.1016/j.anndiagpath.2024.152351

DO - 10.1016/j.anndiagpath.2024.152351

M3 - Review article

C2 - 39004038

AN - SCOPUS:85198067135

SN - 1092-9134

VL - 73

JO - Annals of Diagnostic Pathology

JF - Annals of Diagnostic Pathology

M1 - 152351

ER -

Systemic diseases affecting the GI tract: A review of clinical and histopathologic manifestations

Abstract

Keywords

ASJC Scopus subject areas

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