Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children

Brion S. Maher; Rebecca H. Bitsko; Angelika H. Claussen; Brenna O’Masta; Audrey Cerles; Joseph R. Holbrook; Zayan Mahmooth; Naomi Chen-Bowers; Ana L.Almeida Rojo; Jennifer W. Kaminski; Margaret Rush

doi:10.1007/s11121-023-01605-2

Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children

Brion S. Maher
, Rebecca H. Bitsko
, Angelika H. Claussen
, Brenna O’Masta
, Audrey Cerles
, Joseph R. Holbrook
, Zayan Mahmooth
, Naomi Chen-Bowers
, Ana L.Almeida Rojo
, Jennifer W. Kaminski
, Margaret Rush

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is characterized by persistent patterns of inattention, hyperactivity, and impulsiveness. Among US children and adolescents aged 3–17 years, 9.4% have a diagnosis of ADHD. Previous research suggests possible links between parental substance use and ADHD among children. We conducted a systematic review and meta-analysis of 86 longitudinal or retrospective studies of prenatal or postnatal alcohol, tobacco, or other parental substance use and substance use disorders and childhood ADHD and its related behavioral dimensions of inattention and hyperactivity-impulsivity. Meta-analyses were grouped by drug class and pre- and postnatal periods with combined sample sizes ranging from 789 to 135,732. Prenatal exposure to alcohol or tobacco and parent substance use disorders were consistently and significantly associated with ADHD among children. Other parental drug use exposures resulted in inconsistent or non-significant findings. Prevention and treatment of parental substance use may have potential for impacts on childhood ADHD.

Original language	English (US)
Pages (from-to)	291-315
Number of pages	25
Journal	Prevention Science
Volume	25
Issue number	Suppl 2
DOIs	https://doi.org/10.1007/s11121-023-01605-2
State	Published - May 2024

Keywords

Attention-deficit/hyperactivity disorder
Meta-analysis
Parent alcohol use
Parent substance use
Parent tobacco use

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Access to Document

10.1007/s11121-023-01605-2

Cite this

Maher, B. S., Bitsko, R. H., Claussen, A. H., O’Masta, B., Cerles, A., Holbrook, J. R., Mahmooth, Z., Chen-Bowers, N., Rojo, A. L. A., Kaminski, J. W., & Rush, M. (2024). Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children. Prevention Science, 25(Suppl 2), 291-315. https://doi.org/10.1007/s11121-023-01605-2

Maher, BS, Bitsko, RH, Claussen, AH, O’Masta, B, Cerles, A, Holbrook, JR, Mahmooth, Z, Chen-Bowers, N, Rojo, ALA, Kaminski, JW & Rush, M 2024, 'Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children', Prevention Science, vol. 25, no. Suppl 2, pp. 291-315. https://doi.org/10.1007/s11121-023-01605-2

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abstract = "Attention-deficit/hyperactivity disorder (ADHD) is characterized by persistent patterns of inattention, hyperactivity, and impulsiveness. Among US children and adolescents aged 3{\textendash}17 years, 9.4\% have a diagnosis of ADHD. Previous research suggests possible links between parental substance use and ADHD among children. We conducted a systematic review and meta-analysis of 86 longitudinal or retrospective studies of prenatal or postnatal alcohol, tobacco, or other parental substance use and substance use disorders and childhood ADHD and its related behavioral dimensions of inattention and hyperactivity-impulsivity. Meta-analyses were grouped by drug class and pre- and postnatal periods with combined sample sizes ranging from 789 to 135,732. Prenatal exposure to alcohol or tobacco and parent substance use disorders were consistently and significantly associated with ADHD among children. Other parental drug use exposures resulted in inconsistent or non-significant findings. Prevention and treatment of parental substance use may have potential for impacts on childhood ADHD.",

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AU - Mahmooth, Zayan

AU - Chen-Bowers, Naomi

AU - Rojo, Ana L.Almeida

AU - Kaminski, Jennifer W.

AU - Rush, Margaret

N1 - Publisher Copyright: © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023.

PY - 2024/5

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Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children

Abstract

Keywords

ASJC Scopus subject areas

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