Synthesis of the 6- and 7-hydroxylated cocaines and pseudococaines

A. P. Kozikowski, D. Simoni, S. Manfredini, M. Roberti, J. Stoelwinder

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In efforts aimed at further exploration of our finding that functionalization of the two-carbon bridge of cocaine can lead to a weak antagonist of cocaine, we report a route of the 6- and 7-hydroxylated analogues by use of the Willstatter synthesis. The hydroxylated derivatives can in principle be used to gain access to a diverse library of 6- and 7-functionalized cocaine analogues.

Original languageEnglish (US)
Pages (from-to)5333-5336
Number of pages4
JournalTetrahedron Letters
Issue number30
StatePublished - Jul 22 1996

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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