Synthesis of pyridine nucleotides by mitochondrial fractions of yeast

Richard A. Lange, Myron K. Jacobson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Washed mitochondrial fractions from yeast catalyze the synthesis of nicotinate mononucleotide and nicotinate adenine dinucleotide from nicotinate or nicotinamide. The synthesis is stimulated 10 fold by sonic disruption of the fractions and shows an absolute requirement for ATP, 5-phosphoribosyl-1-pyrophosphate, and MgCl2.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - May 23 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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