Synthesis of N1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

Jayanta Kumar Mukhopadhyaya; Alan P. Kozikowski; Ewa Grajkowska; Sergey Pshenichkin; Jarda T. Wroblewski

doi:10.1016/S0960-894X(01)00329-8

Synthesis of N¹-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

Jayanta Kumar Mukhopadhyaya
, Alan P. Kozikowski
, Ewa Grajkowska
, Sergey Pshenichkin
, Jarda T. Wroblewski

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The chemical synthesis of a series of N¹-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid [(2R,4R)-APDC] as constrained analogues of γ-substituted glutamic acids is described. Appropriate substitution of the N¹-position results in agonist, partial agonist, or antagonist activity at mGluR2, mGluR3, and/or mGluR6.

Original language	English (US)
Pages (from-to)	1919-1924
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(01)00329-8
State	Published - Jul 23 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00329-8

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Mukhopadhyaya, J. K., Kozikowski, A. P., Grajkowska, E., Pshenichkin, S., & Wroblewski, J. T. (2001). Synthesis of N¹-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. Bioorganic and Medicinal Chemistry Letters, 11(14), 1919-1924. https://doi.org/10.1016/S0960-894X(01)00329-8

Synthesis of N¹-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. / Mukhopadhyaya, Jayanta Kumar; Kozikowski, Alan P.; Grajkowska, Ewa et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 14, 23.07.2001, p. 1919-1924.

Research output: Contribution to journal › Article › peer-review

Mukhopadhyaya, JK, Kozikowski, AP, Grajkowska, E, Pshenichkin, S & Wroblewski, JT 2001, 'Synthesis of N¹-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors', Bioorganic and Medicinal Chemistry Letters, vol. 11, no. 14, pp. 1919-1924. https://doi.org/10.1016/S0960-894X(01)00329-8

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AU - Kozikowski, Alan P.

AU - Grajkowska, Ewa

AU - Pshenichkin, Sergey

AU - Wroblewski, Jarda T.

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Synthesis of N¹-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors

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