Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abdul H. Fauq; Javid H. Zaidi; Robert A. Wilcox; Girlie Varvel; Stefan R. Nahorski; Alan P. Kozikowski; Christophé Erneux

doi:10.1016/0040-4039(96)00169-4

Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abdul H. Fauq
, Javid H. Zaidi
, Robert A. Wilcox
, Girlie Varvel
, Stefan R. Nahorski
, Alan P. Kozikowski
, Christophé Erneux

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP₃), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

Original language	English (US)
Pages (from-to)	1917-1920
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	12
DOIs	https://doi.org/10.1016/0040-4039(96)00169-4
State	Published - Mar 18 1996

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(96)00169-4

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title = "Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate",

abstract = "Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.",

author = "Fauq, \{Abdul H.\} and Zaidi, \{Javid H.\} and Wilcox, \{Robert A.\} and Girlie Varvel and Nahorski, \{Stefan R.\} and Kozikowski, \{Alan P.\} and Christoph{\'e} Erneux",

year = "1996",

month = mar,

day = "18",

doi = "10.1016/0040-4039(96)00169-4",

language = "English (US)",

volume = "37",

pages = "1917--1920",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

AU - Fauq, Abdul H.

AU - Zaidi, Javid H.

AU - Wilcox, Robert A.

AU - Varvel, Girlie

AU - Nahorski, Stefan R.

AU - Kozikowski, Alan P.

AU - Erneux, Christophé

PY - 1996/3/18

Y1 - 1996/3/18

N2 - Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

AB - Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP3), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

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U2 - 10.1016/0040-4039(96)00169-4

DO - 10.1016/0040-4039(96)00169-4

M3 - Article

AN - SCOPUS:0029933523

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SP - 1917

EP - 1920

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 12

ER -

Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

Abstract

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