Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

David H. Rosenblatt; Marvin M. Nachlas; Arnold M. Seligman

doi:10.1021/ja01543a029

Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

David H. Rosenblatt, Marvin M. Nachlas, Arnold M. Seligman

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamine have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.

Original language	English (US)
Pages (from-to)	2463-2465
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	80
Issue number	10
DOIs	https://doi.org/10.1021/ja01543a029
State	Published - May 1 1958
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates",

abstract = "Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamine have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.",

author = "Rosenblatt, {David H.} and Nachlas, {Marvin M.} and Seligman, {Arnold M.}",

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T1 - Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

AU - Rosenblatt, David H.

AU - Nachlas, Marvin M.

AU - Seligman, Arnold M.

PY - 1958/5/1

Y1 - 1958/5/1

N2 - Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamine have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.

AB - Because of the expected greater rate of coupling as compared to naphthylamine, 3-methoxy-1-naphthylamine and 4-methoxy-2-naphthylamine have been synthesized for use in the preparation of chromogenic substrates for the histochemical demonstration of amidases and peptidases. The chloroacetamides, trifluoroacetamides and L-leucyl-4-methoxy-2-naphthyl amide also were prepared. The last derivative is a superior reagent for the histochemical demonstration of leucine amino peptidase.

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Synthesis of m-Methoxynaphthylamines as Precursors for Chromogenic Substrates

Abstract

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