Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

Renliang Yang; Kalyan Kumar Pasunooti; Fupeng Li; Xue Wei Liu; Chuan Fa Liu

doi:10.1039/c0cc01382j

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

Renliang Yang
, Kalyan Kumar Pasunooti
, Fupeng Li
, Xue Wei Liu
, Chuan Fa Liu

Research output: Contribution to journal › Article › peer-review

Abstract

The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.

Original language	English (US)
Pages (from-to)	7199-7201
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	38
DOIs	https://doi.org/10.1039/c0cc01382j
State	Published - Oct 14 2010
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c0cc01382j

Cite this

@article{97833c05eef14cd9b900391296350a83,

title = "Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine",

abstract = "The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.",

author = "Renliang Yang and Pasunooti, \{Kalyan Kumar\} and Fupeng Li and Liu, \{Xue Wei\} and Liu, \{Chuan Fa\}",

year = "2010",

month = oct,

day = "14",

doi = "10.1039/c0cc01382j",

language = "English (US)",

volume = "46",

pages = "7199--7201",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "38",

}

TY - JOUR

T1 - Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

AU - Yang, Renliang

AU - Pasunooti, Kalyan Kumar

AU - Li, Fupeng

AU - Liu, Xue Wei

AU - Liu, Chuan Fa

PY - 2010/10/14

Y1 - 2010/10/14

N2 - The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.

AB - The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.

UR - https://www.scopus.com/pages/publications/77956841522

UR - https://www.scopus.com/pages/publications/77956841522#tab=citedBy

U2 - 10.1039/c0cc01382j

DO - 10.1039/c0cc01382j

M3 - Article

C2 - 20737108

AN - SCOPUS:77956841522

SN - 1359-7345

VL - 46

SP - 7199

EP - 7201

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this