Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

Alan P. Kozikowski; Garth Powis; Alfred Gallegos; Werner Tückmantel

doi:10.1016/S0960-894X(00)80340-6

Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

Alan P. Kozikowski, Garth Powis, Alfred Gallegos, Werner Tückmantel

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The title compounds were synthesized in optically pure form from L-quebrachitol via the known 3-homologated inositol derivative 1; also prepared were D-3-deoxy-3-methylene-, -3-(hydroxymethyl)-, and -3-(iodomethyl)-myo-inositol. None of these compounds significantly inhibited the growth of wild type and v-sis-transformed NIH 3T3 cells at millimolar concentration.

Original language	English (US)
Pages (from-to)	1323-1326
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)80340-6
State	Published - Jun 1993
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80340-6

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title = "Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway",

abstract = "The title compounds were synthesized in optically pure form from L-quebrachitol via the known 3-homologated inositol derivative 1; also prepared were D-3-deoxy-3-methylene-, -3-(hydroxymethyl)-, and -3-(iodomethyl)-myo-inositol. None of these compounds significantly inhibited the growth of wild type and v-sis-transformed NIH 3T3 cells at millimolar concentration.",

author = "Kozikowski, {Alan P.} and Garth Powis and Alfred Gallegos and Werner T{\"u}ckmantel",

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T1 - Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

AU - Kozikowski, Alan P.

AU - Powis, Garth

AU - Gallegos, Alfred

AU - Tückmantel, Werner

PY - 1993/6

Y1 - 1993/6

N2 - The title compounds were synthesized in optically pure form from L-quebrachitol via the known 3-homologated inositol derivative 1; also prepared were D-3-deoxy-3-methylene-, -3-(hydroxymethyl)-, and -3-(iodomethyl)-myo-inositol. None of these compounds significantly inhibited the growth of wild type and v-sis-transformed NIH 3T3 cells at millimolar concentration.

AB - The title compounds were synthesized in optically pure form from L-quebrachitol via the known 3-homologated inositol derivative 1; also prepared were D-3-deoxy-3-methylene-, -3-(hydroxymethyl)-, and -3-(iodomethyl)-myo-inositol. None of these compounds significantly inhibited the growth of wild type and v-sis-transformed NIH 3T3 cells at millimolar concentration.

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JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

Abstract

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