Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Jason A. Smulik; Steven T. Diver; Fan Pan; Jun O. Liu

doi:10.1021/ol0258987

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Jason A. Smulik, Steven T. Diver, Fan Pan, Jun O. Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

(Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

Original language	English (US)
Pages (from-to)	2051-2054
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	12
DOIs	https://doi.org/10.1021/ol0258987
State	Published - Jun 13 2002

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0258987

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@article{81558ac672ee4b9392667deb7653d187,

title = "Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis",

abstract = "(Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.",

author = "Smulik, {Jason A.} and Diver, {Steven T.} and Fan Pan and Liu, {Jun O.}",

year = "2002",

month = jun,

day = "13",

doi = "10.1021/ol0258987",

language = "English (US)",

volume = "4",

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journal = "Organic Letters",

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T1 - Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

AU - Smulik, Jason A.

AU - Diver, Steven T.

AU - Pan, Fan

AU - Liu, Jun O.

PY - 2002/6/13

Y1 - 2002/6/13

N2 - (Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

AB - (Matrix Presented) New affinity reagents were synthesized using alkene metathesis to directly modify the MeBmt side chain of cyclosporin A. The reagents were used to detect novel cyclophilins from cellular extracts.

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U2 - 10.1021/ol0258987

DO - 10.1021/ol0258987

M3 - Article

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EP - 2054

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Synthesis of Cyclosporin A-Derived Affinity Reagents by Olefin Metathesis

Abstract

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