Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity

Theodore P. Goldstein; Robert E. Plapinger; Marvin M. Nachlas; Arnold M. Seligman

doi:10.1021/jm01239a020

Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity

Theodore P. Goldstein, Robert E. Plapinger, Marvin M. Nachlas, Arnold M. Seligman

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The 2-naphthylamides of six amino acids were prepared as substrates in order to determine if the enzymatic splitting of the amide link is due to a non-specific aminopeptidase or an aminopeptidase specific for each amino acid.

Original language	English (US)
Pages (from-to)	852-857
Number of pages	6
Journal	Journal of Medicinal and Pharmaceutical Chemistry
Volume	5
Issue number	4
DOIs	https://doi.org/10.1021/jm01239a020
State	Published - Jul 1 1962

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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@article{54621bc3025540fb82cc1f1adcbd5297,

title = "Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity",

abstract = "The 2-naphthylamides of six amino acids were prepared as substrates in order to determine if the enzymatic splitting of the amide link is due to a non-specific aminopeptidase or an aminopeptidase specific for each amino acid.",

author = "Goldstein, {Theodore P.} and Plapinger, {Robert E.} and Nachlas, {Marvin M.} and Seligman, {Arnold M.}",

year = "1962",

month = jul,

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doi = "10.1021/jm01239a020",

language = "English (US)",

volume = "5",

pages = "852--857",

journal = "Journal of Medicinal and Pharmaceutical Chemistry",

issn = "0095-9065",

publisher = "American Chemical Society",

number = "4",

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T1 - Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity

AU - Goldstein, Theodore P.

AU - Plapinger, Robert E.

AU - Nachlas, Marvin M.

AU - Seligman, Arnold M.

PY - 1962/7/1

Y1 - 1962/7/1

N2 - The 2-naphthylamides of six amino acids were prepared as substrates in order to determine if the enzymatic splitting of the amide link is due to a non-specific aminopeptidase or an aminopeptidase specific for each amino acid.

AB - The 2-naphthylamides of six amino acids were prepared as substrates in order to determine if the enzymatic splitting of the amide link is due to a non-specific aminopeptidase or an aminopeptidase specific for each amino acid.

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U2 - 10.1021/jm01239a020

DO - 10.1021/jm01239a020

M3 - Article

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AN - SCOPUS:33947480279

SN - 0095-9065

VL - 5

SP - 852

EP - 857

JO - Journal of Medicinal and Pharmaceutical Chemistry

JF - Journal of Medicinal and Pharmaceutical Chemistry

IS - 4

ER -

Synthesis of Chromogenic Substrates for the Assay of Aminopeptidase Activity

Abstract

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