Abstract
A short synthesis of a hydroxyethylene dipeptide isostere, a core unit of the HIV protease inhibitors ritonavir and lopinavir, and its C-5 epimer is described.
Original language | English (US) |
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Article number | Z11008SS |
Pages (from-to) | 3061-3064 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 19 |
DOIs | |
State | Published - Oct 1 2008 |
Externally published | Yes |
Keywords
- HIV-AIDS
- Peptidomimetic aspartyl protease inhibitors
- Regioselective epoxide opening
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry