Synthesis of 5-Methylene-2-pyrrolones

Marco Paolo Jacinto; Patricio Pichling; Marc M. Greenberg

doi:10.1021/acs.orglett.8b02030

Synthesis of 5-Methylene-2-pyrrolones

Marco Paolo Jacinto, Patricio Pichling, Marc M. Greenberg

Krieger School of Arts and Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.

Original language	English (US)
Pages (from-to)	4885-4887
Number of pages	3
Journal	Organic Letters
Volume	20
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.8b02030
State	Published - Aug 17 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.8b02030

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title = "Synthesis of 5-Methylene-2-pyrrolones",

abstract = "A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.",

author = "Jacinto, {Marco Paolo} and Patricio Pichling and Greenberg, {Marc M.}",

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doi = "10.1021/acs.orglett.8b02030",

language = "English (US)",

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AU - Pichling, Patricio

AU - Greenberg, Marc M.

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N2 - A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.

AB - A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.

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Synthesis of 5-Methylene-2-pyrrolones

Abstract

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