Synthesis of 5-Methylene-2-pyrrolones

Marco Paolo Jacinto, Patricio Pichling, Marc M. Greenberg

Research output: Contribution to journalArticlepeer-review


A facile, one-pot synthetic method for the synthesis of 5-methylene-2-pyrrolones (5MPs) from inexpensive furfuryl acetate is described. Bromine oxidation and trapping of the in situ generated 1,4-dicarbonyl compound by a primary amine provided the corresponding 5MPs in 50-69% yield.

Original languageEnglish (US)
Pages (from-to)4885-4887
Number of pages3
JournalOrganic Letters
Issue number16
StatePublished - Aug 17 2018

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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