Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

Andrew G. Horti; Hayden T. Ravert; William B. Mathews; Edward H. Abraham; Richard L. Wahl; Robert F. Dannals

doi:10.1002/jlcr.1097

Synthesis of 2-[¹⁸F]fluoroadenosine (2-[¹⁸F]FAD) as potential radiotracer for studying malignancies by PET

Andrew G. Horti
, Hayden T. Ravert
, William B. Mathews
, Edward H. Abraham
, Richard L. Wahl
, Robert F. Dannals

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

2-[¹⁸F]fluoroadenosine (2-[¹⁸F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[¹⁸F]FAD were 5%, 22-30 mCi/μmol and 99%, and 0.5%, 1200-1700 mCi/μmol and 99%, respectively.

Original language	English (US)
Pages (from-to)	811-815
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	49
Issue number	9
DOIs	https://doi.org/10.1002/jlcr.1097
State	Published - Aug 2006

Keywords

2-[F] fluoroadenosine
Adenylate metabolism
Cancer
F
Positron emission tomography

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.1097

Cite this

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title = "Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET",

abstract = "2-[18F]fluoroadenosine (2-[18F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[18F]FAD were 5\%, 22-30 mCi/μmol and 99\%, and 0.5\%, 1200-1700 mCi/μmol and 99\%, respectively.",

keywords = "2-[F] fluoroadenosine, Adenylate metabolism, Cancer, F, Positron emission tomography",

author = "Horti, \{Andrew G.\} and Ravert, \{Hayden T.\} and Mathews, \{William B.\} and Abraham, \{Edward H.\} and Wahl, \{Richard L.\} and Dannals, \{Robert F.\}",

year = "2006",

month = aug,

doi = "10.1002/jlcr.1097",

language = "English (US)",

volume = "49",

pages = "811--815",

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T1 - Synthesis of 2-[18F]fluoroadenosine (2-[18F]FAD) as potential radiotracer for studying malignancies by PET

AU - Horti, Andrew G.

AU - Ravert, Hayden T.

AU - Mathews, William B.

AU - Abraham, Edward H.

AU - Wahl, Richard L.

AU - Dannals, Robert F.

PY - 2006/8

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AB - 2-[18F]fluoroadenosine (2-[18F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[18F]FAD were 5%, 22-30 mCi/μmol and 99%, and 0.5%, 1200-1700 mCi/μmol and 99%, respectively.

KW - 2-[F] fluoroadenosine

KW - Adenylate metabolism

KW - Cancer

KW - F

KW - Positron emission tomography

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