Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

S. Sakamuri; I. J. Enyedy; A. P. Kozikowski; S. Wang

doi:10.1016/S0040-4039(00)01810-4

Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

S. Sakamuri, I. J. Enyedy, A. P. Kozikowski, S. Wang

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	9949-9952
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	51
DOIs	https://doi.org/10.1016/S0040-4039(00)01810-4
State	Published - Dec 16 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)01810-4

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title = "Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors",

abstract = "The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.",

author = "S. Sakamuri and Enyedy, {I. J.} and Kozikowski, {A. P.} and S. Wang",

note = "Funding Information: We are indebted to the National Institute on Drug Abuse (NIDA), National Institute of Health for their financial support of this work (DA-11545).",

year = "2000",

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doi = "10.1016/S0040-4039(00)01810-4",

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T1 - Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

AU - Sakamuri, S.

AU - Enyedy, I. J.

AU - Kozikowski, A. P.

AU - Wang, S.

N1 - Funding Information: We are indebted to the National Institute on Drug Abuse (NIDA), National Institute of Health for their financial support of this work (DA-11545).

PY - 2000/12/16

Y1 - 2000/12/16

N2 - The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.

AB - The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.

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U2 - 10.1016/S0040-4039(00)01810-4

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

Abstract

ASJC Scopus subject areas

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