Synthesis of (±)-10,10-dimethylhuperzine A - A huperzine analogue possessing a slower enzyme off-rate

Alan P. Kozikowski, Qingjie Ding, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The synthesis of (±)-10,10-dimethylhuperzine A is reported together with its kinetic (kon and koff) and dissociation constants for the inhibition of fetal bovine serum acetylcholinesterase. While somewhat more potent than (±)-huperzine A, the dimethyl analogue shows a slower off-rate from AChE, a result that may be of potential therapeutic value.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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