(matrix presented) Both (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy-8-(1-decynyl)benzolactam-V8 were designed and synthesized as PKC modulators. Biological assays reveal the (6R)-ligand to be 20-fold more potent than its (6S)-counterpart in binding to PKCα.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 27 2002|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry