Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

Yousef Ahmadibeni; Keykavous Parang

doi:10.1002/anie.200605029

Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

Yousef Ahmadibeni, Keykavous Parang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	4739-4743
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	25
DOIs	https://doi.org/10.1002/anie.200605029
State	Published - 2007
Externally published	Yes

Keywords

CD spectropolarimetry
Diphosphodiesters
Nucleotides
Solid-phase synthesis
Thermal analysis

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/anie.200605029

Cite this

@article{b4a34d918ba8431c93a3aba4ae9679f1,

title = "Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages",

abstract = "Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented).",

keywords = "CD spectropolarimetry, Diphosphodiesters, Nucleotides, Solid-phase synthesis, Thermal analysis",

author = "Yousef Ahmadibeni and Keykavous Parang",

year = "2007",

doi = "10.1002/anie.200605029",

language = "English (US)",

volume = "46",

pages = "4739--4743",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "25",

}

TY - JOUR

T1 - Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

AU - Ahmadibeni, Yousef

AU - Parang, Keykavous

PY - 2007

Y1 - 2007

N2 - Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented).

AB - Build a bridge: Oligodeoxynucleotides (ODNs) containing diphosphodiester bridges were synthesized by a solid-phase synthesis strategy. Modified ODNs formed stable duplexes with complementary modified and unmodified nucleic acid sequences. The modified oligomers were resistant to degradation by DNase I and 3′-exonuclease I under conditions in which unmodified ODNs were degraded. B = T, A, G, or C. (Chemical Equation Presented).

KW - CD spectropolarimetry

KW - Diphosphodiesters

KW - Nucleotides

KW - Solid-phase synthesis

KW - Thermal analysis

UR - http://www.scopus.com/inward/record.url?scp=34347263055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347263055&partnerID=8YFLogxK

U2 - 10.1002/anie.200605029

DO - 10.1002/anie.200605029

M3 - Article

C2 - 17497623

AN - SCOPUS:34347263055

SN - 1433-7851

VL - 46

SP - 4739

EP - 4743

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 25

ER -

Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this