Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors

A. Rafinejad; A. Fallah-Tafti; R. Tiwari; A. Nasrolahi Shirazi; D. Mandal; K. Parang; A. Foroumadi; T. Akbarzadeh

Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors

A. Rafinejad, A. Fallah-Tafti, R. Tiwari, A. Nasrolahi Shirazi, D. Mandal, K. Parang, A. Foroumadi, T. Akbarzadeh

Research output: Contribution to journal › Article › peer-review

Abstract

In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.

Original language	English (US)
Pages (from-to)	321-325
Number of pages	5
Journal	Journal of Sciences, Islamic Republic of Iran
Volume	26
Issue number	4
State	Published - Sep 1 2015
Externally published	Yes

Keywords

Cancer
Ethyl 2,4-dioxo-4-arylbutanoates
Src Kinase

ASJC Scopus subject areas

General

Cite this

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title = "Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors",

abstract = "In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.",

keywords = "Cancer, Ethyl 2,4-dioxo-4-arylbutanoates, Src Kinase",

author = "A. Rafinejad and A. Fallah-Tafti and R. Tiwari and Shirazi, {A. Nasrolahi} and D. Mandal and K. Parang and A. Foroumadi and T. Akbarzadeh",

year = "2015",

month = sep,

day = "1",

language = "English (US)",

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pages = "321--325",

journal = "Journal of Sciences, Islamic Republic of Iran",

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TY - JOUR

T1 - Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors

AU - Rafinejad, A.

AU - Fallah-Tafti, A.

AU - Tiwari, R.

AU - Shirazi, A. Nasrolahi

AU - Mandal, D.

AU - Parang, K.

AU - Foroumadi, A.

AU - Akbarzadeh, T.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.

AB - In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.

KW - Cancer

KW - Ethyl 2,4-dioxo-4-arylbutanoates

KW - Src Kinase

UR - http://www.scopus.com/inward/record.url?scp=84954560805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954560805&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84954560805

SN - 1016-1104

VL - 26

SP - 321

EP - 325

JO - Journal of Sciences, Islamic Republic of Iran

JF - Journal of Sciences, Islamic Republic of Iran

IS - 4

ER -

Synthesis and evaluation of ethyl 2,4-dioxo-4-arylbutanoate derivatives as Src Kinase inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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