Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

David C. Limburg; Bert E. Thomas IV; Jia He Li; Mike Fuller; Dawn Spicer; Yi Chen; Hongzhi Guo; Joseph P. Steiner; Gregory S. Hamilton; Yong Qian Wu

doi:10.1016/S0960-894X(03)00758-3

Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

David C. Limburg, Bert E. Thomas IV, Jia He Li, Mike Fuller, Dawn Spicer, Yi Chen, Hongzhi Guo, Joseph P. Steiner, Gregory S. Hamilton, Yong Qian Wu

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.

Original language	English (US)
Pages (from-to)	3867-3870
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	21
DOIs	https://doi.org/10.1016/S0960-894X(03)00758-3
State	Published - Nov 3 2003

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(03)00758-3

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title = "Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands",

abstract = "As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.",

author = "Limburg, {David C.} and {Thomas IV}, {Bert E.} and Li, {Jia He} and Mike Fuller and Dawn Spicer and Yi Chen and Hongzhi Guo and Steiner, {Joseph P.} and Hamilton, {Gregory S.} and Wu, {Yong Qian}",

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T1 - Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

AU - Limburg, David C.

AU - Thomas IV, Bert E.

AU - Li, Jia He

AU - Fuller, Mike

AU - Spicer, Dawn

AU - Chen, Yi

AU - Guo, Hongzhi

AU - Steiner, Joseph P.

AU - Hamilton, Gregory S.

AU - Wu, Yong Qian

PY - 2003/11/3

Y1 - 2003/11/3

N2 - As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.

AB - As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 21

ER -

Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

Abstract

ASJC Scopus subject areas

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