Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro

Franco Chimenti; Bruna Bizzarri; Adriana Bolasco; Daniela Secci; Paola Chimenti; Simone Carradori; Arianna Granese; Daniela Rivanera; Nathan Frishberg; Claudia Bordón; Lorraine Jones-Brando

doi:10.1021/jm9005862

Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro

Franco Chimenti, Bruna Bizzarri, Adriana Bolasco, Daniela Secci, Paola Chimenti, Simone Carradori, Arianna Granese, Daniela Rivanera, Nathan Frishberg, Claudia Bordón, Lorraine Jones-Brando

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18 Scopus citations

Abstract

A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.

Original language	English (US)
Pages (from-to)	4574-4577
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	52
Issue number	15
DOIs	https://doi.org/10.1021/jm9005862
State	Published - Aug 13 2009
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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title = "Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro",

abstract = "A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.",

author = "Franco Chimenti and Bruna Bizzarri and Adriana Bolasco and Daniela Secci and Paola Chimenti and Simone Carradori and Arianna Granese and Daniela Rivanera and Nathan Frishberg and Claudia Bord{\'o}n and Lorraine Jones-Brando",

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T1 - Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro

AU - Chimenti, Franco

AU - Bizzarri, Bruna

AU - Bolasco, Adriana

AU - Secci, Daniela

AU - Chimenti, Paola

AU - Carradori, Simone

AU - Granese, Arianna

AU - Rivanera, Daniela

AU - Frishberg, Nathan

AU - Bordón, Claudia

AU - Jones-Brando, Lorraine

PY - 2009/8/13

Y1 - 2009/8/13

N2 - A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.

AB - A new series of 4-acyl-2-thiazolylhydrazone derivatives was synthesized and screened for its in vitro activity against Toxoplasma gondii. We evaluated parasite growth inhibition and cytotoxicity, inhibition of replication, and inhibition of parasite invasion of host cells. The biological results indicated that some substances had an antiproliferative effect against intracellular T. gondii tachyzoites cultivated in vitro.

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U2 - 10.1021/jm9005862

DO - 10.1021/jm9005862

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JO - Journal of medicinal chemistry

JF - Journal of medicinal chemistry

IS - 15

ER -

Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in vitro

Abstract

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