Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives

Yakini Brandy; Nailah Brandy; Emmanuel Akinboye; Malik Lewis; Claudia Mouamba; Seshat MacK; Ray J. Butcher; Alan J. Anderson; Oladapo Bakare

doi:10.3390/molecules18021973

Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives

Yakini Brandy, Nailah Brandy, Emmanuel Akinboye, Malik Lewis, Claudia Mouamba, Seshat MacK, Ray J. Butcher, Alan J. Anderson, Oladapo Bakare

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.

Original language	English (US)
Pages (from-to)	1973-1984
Number of pages	12
Journal	Molecules
Volume	18
Issue number	2
DOIs	https://doi.org/10.3390/molecules18021973
State	Published - Feb 2013
Externally published	Yes

Keywords

1,4-naphthoquinone
Imide synthesis
Sodium hydride-promoted bis-acylation
Unsymmetrical imide

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules18021973

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abstract = "Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.",

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author = "Yakini Brandy and Nailah Brandy and Emmanuel Akinboye and Malik Lewis and Claudia Mouamba and Seshat MacK and Butcher, {Ray J.} and Anderson, {Alan J.} and Oladapo Bakare",

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AU - Brandy, Yakini

AU - Brandy, Nailah

AU - Akinboye, Emmanuel

AU - Lewis, Malik

AU - Mouamba, Claudia

AU - MacK, Seshat

AU - Butcher, Ray J.

AU - Anderson, Alan J.

AU - Bakare, Oladapo

PY - 2013/2

Y1 - 2013/2

N2 - Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.

AB - Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino- 1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4- naphthoquinone, 2-amino-3-bromo- 1,4-naphthoquinone and 2-amino-3-methoxy-1,4- naphthoquinone.

KW - 1,4-naphthoquinone

KW - Imide synthesis

KW - Sodium hydride-promoted bis-acylation

KW - Unsymmetrical imide

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Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives

Abstract

Keywords

ASJC Scopus subject areas

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