Synthesis and biological evaluation of (±)-Z-huperzine A

Alan P. Kozikowski, Fumio Yamada, X. C. Tang, Israel Hanin

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The synthesis of (±)-Z-huperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. The compound has an IC50 of 6 x 10-6 M, which is comparable to that of huperzine B.

Original languageEnglish (US)
Pages (from-to)6159-6162
Number of pages4
JournalTetrahedron Letters
Issue number43
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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