Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy

Cordula Grüttner; Knut Müller; Joachim Teller; Fritz Westphal; Allan Foreman; Robert Ivkov

doi:10.1016/j.jmmm.2006.10.1151

Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy

Cordula Grüttner, Knut Müller, Joachim Teller, Fritz Westphal, Allan Foreman, Robert Ivkov

Research output: Contribution to journal › Article › peer-review

125 Scopus citations

Abstract

Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immunoreactivity of the final antibody-particle conjugate.

Original language	English (US)
Pages (from-to)	181-186
Number of pages	6
Journal	Journal of Magnetism and Magnetic Materials
Volume	311
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jmmm.2006.10.1151
State	Published - Apr 2007
Externally published	Yes

Keywords

Alternating magnetic field
Antibody conjugation
Cancer therapy
Hyperthermia
Magnetic nanoparticle
Specific power absorption rate

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1016/j.jmmm.2006.10.1151

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Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy. / Grüttner, Cordula; Müller, Knut; Teller, Joachim et al.
In: Journal of Magnetism and Magnetic Materials, Vol. 311, No. 1 SPEC. ISS., 04.2007, p. 181-186.

Research output: Contribution to journal › Article › peer-review

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title = "Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy",

abstract = "Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immunoreactivity of the final antibody-particle conjugate.",

keywords = "Alternating magnetic field, Antibody conjugation, Cancer therapy, Hyperthermia, Magnetic nanoparticle, Specific power absorption rate",

author = "Cordula Gr{\"u}ttner and Knut M{\"u}ller and Joachim Teller and Fritz Westphal and Allan Foreman and Robert Ivkov",

note = "Funding Information: This work is supported by the US Army Medical Research and Material Command under Contract No. W81XWH-04-C-0142. The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision so designated by other documentation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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AU - Grüttner, Cordula

AU - Müller, Knut

AU - Teller, Joachim

AU - Westphal, Fritz

AU - Foreman, Allan

AU - Ivkov, Robert

N1 - Funding Information: This work is supported by the US Army Medical Research and Material Command under Contract No. W81XWH-04-C-0142. The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision so designated by other documentation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

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AB - Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immunoreactivity of the final antibody-particle conjugate.

KW - Alternating magnetic field

KW - Antibody conjugation

KW - Cancer therapy

KW - Hyperthermia

KW - Magnetic nanoparticle

KW - Specific power absorption rate

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Synthesis and antibody conjugation of magnetic nanoparticles with improved specific power absorption rates for alternating magnetic field cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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