Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Alan P. Kozikowski; Giuseppe Campiani; Ashima Saxena; Bhupendra P. Doctor

doi:10.1039/C39950000283

Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Alan P. Kozikowski, Giuseppe Campiani, Ashima Saxena, Bhupendra P. Doctor

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

Original language	English (US)
Pages (from-to)	283-285
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	2
DOIs	https://doi.org/10.1039/C39950000283
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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10.1039/C39950000283

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title = "Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A",

abstract = "Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.",

author = "Kozikowski, {Alan P.} and Giuseppe Campiani and Ashima Saxena and Doctor, {Bhupendra P.}",

year = "1995",

doi = "10.1039/C39950000283",

language = "English (US)",

pages = "283--285",

journal = "Journal of the Chemical Society, Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "2",

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T1 - Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

AU - Kozikowski, Alan P.

AU - Campiani, Giuseppe

AU - Saxena, Ashima

AU - Doctor, Bhupendra P.

PY - 1995

Y1 - 1995

N2 - Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

AB - Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

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U2 - 10.1039/C39950000283

DO - 10.1039/C39950000283

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ER -

Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Abstract

ASJC Scopus subject areas

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